Delta-like protein 3 (DLL3) is an inhibitory protein of Notch signaling that is involved in embryonic patterning and has been implicated in neuroendocrine cell development.1 DLL3 is typically located in the Golgi apparatus and cytoplasmic vesicles, where it inhibits Notch signaling by preventing the processing and cell surface expression of Notch.2
In high-grade neuroendocrine tumors—including small cell lung cancer (SCLC)—DLL3 is upregulated and expressed on the cell surface, with absent or rare expression on nonmalignant cells.1,3 This makes DLL3 an attractive potential target for investigating a BiTE® molecule aimed at neuroendocrine tumors, such as SCLC.
Learn more about modalities targeting DLL3:
Watch this video for an overview of the role of DLL3 in SCLC and the mechanism of action of a DLL3-targeted BiTE® molecule.
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Visit our resources section for additional information on potential oncogenic targets.
1. Sabari JK, Lok BH, Laird JH, Poirier JT, Rudin CM. Nat Rev Clin Oncol. 2017;14(9):549-561. 2. Chapman G, Sparrow DB, Kremmer E, Dunwoodie SL. Hum Mol Genet. 2011;20(5):905-916. doi:10.1093/hmg/ddq529. 3. Leonetti A, et al. Cell Oncol (Dordr). 2019;42:261-273.