MUC17

Mucin 17 (MUC17) is a transmembrane protein that is expressed on the apical surface of gastrointestinal epithelial cells and is a key component of the mucosal layer.1,2 MUC17 is overexpressed in about half of gastric cancers, where it exhibits multifocal membranous staining on tumor cells.3-6 MUC17 is a compelling target in gastric cancer due to its prevalent expression on tumor cells as compared to the low, relatively restricted expression in normal tissues.1,3

 

Learn more about modalities targeting MUC17:
HLE BiTE® technology.

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References

1. van Putten JPM, Strijbis K. J Innate Immun. 2017;9(3):281-299. 2. Kufe DW. Nat Rev Cancer. 2009;9(12):874-885. 3. Bailis JM, Lutterbuese P, Thomas O, et al. Presented at: AACR Virtual Annual Meeting II; June 22-24, 2020. Poster 3364. 4. Yang B, Wu A, Hu Y, et al. J Exp Clin Cancer Res. 2019;38(1):283. 5. Lin S, Zhang Y, Hu Y, et al. Gastric Cancer. 2019;22(5):941-954. 6. Lordick F, Buxó E, Cervantes A, et al. Presented at: ESMO World Congress on Gastrointestinal Cancer; July 1-4, 2020; Virtual. Poster-076.