Mucin 17 (MUC17) is a member of the mucin family of proteins. Mucins are key components of the mucosal barrier in the gastrointestinal tract that protect epithelia from the carcinogenic effects of chronic inflammation.1,2 MUC17 is a transmembrane protein expressed on the apical membrane of normal gastrointestinal mucosal epithelial cells, and may serve as a cellular receptor through its extended, repetitive extracellular glycosylation domain.1-3
MUC17 is overexpressed in cancers of epithelial origin and is more highly expressed in gastric cancer cells.2-4
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1. van Putten JPM, Strijbis K. J Innate Immun. 2017;9(3):281-299. 2. Kufe DW. Nat Rev Cancer. 2009;9(12):874-885. 3. Gum JR, Crawley SC, Hicks JW, et al. Biochem Biophys Res Commun. 2002;291(3):466-475. 4. Yang B, Wu A, Hu Y, et al. J Exp Clin Cancer Res. 2019;38(1):283.