CD38

CD38 is a transmembrane glycoprotein found on the surface of immune cells, including a range of bone marrow cells. In peripheral blood, CD38 is expressed on approximately 90% of plasma cells and approximately 60% of natural killer cells and monocytes. In normal cells, CD38 has many roles, in some instances stimulating lymphocytes, and in other circumstances inhibiting cell growth in B cell precursors.¹

CD38 is an attractive target for antibody therapy because it is highly expressed on malignant plasma cells.² In multiple myeloma, more than 90% of malignant plasma cells show surface expression of CD38. Expression is also seen in B cell and T cell neoplasms.

Learn more about modalities targeting CD38:
XmAb^® technology.

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CD: cluster of differentiation.