Tight junction molecule claudin-18 isoform 2 (CLDN18.2) is a member of the claudin family of proteins, which includes tight junction proteins that establish paracellular barriers to control the flow of molecules between cells.1,2 CLDN18.2 is highly expressed in the healthy stomach and is strictly confined to differentiated epithelial cells of the gastric mucosa.3

Recent studies have identified CLDN18.2 as a promising target in gastric cancer therapy. CLDN18.2 is overexpressed in a significant proportion of gastric cancers and esophageal adenocarcinomas. The restricted expression makes it an attractive target for the treatment of gastric and esophageal adenocarcinoma.3


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1. National Center for Biotechnology Information. Accessed May 14, 2020.2. Furuse M, Fujita K, Hiiragi T, et al. J Cell Biol. 1998;141(7):1539-1550. 3. Zhu G, Foletti D, Liu X, et al. Sci Rep. 2019;9(1):8420.