Tight junction molecule claudin-18 isoform 2 (CLDN18.2) is a member of the claudin family of proteins, which includes tight junction proteins that establish paracellular barriers to control the flow of molecules between cells.1 CLDN18.2 is normally found in the cellular tight junctions of gastric mucosa and intestinal epithelium.1,2 In the healthy stomach, it is strictly confined to differentiated epithelial cells of the gastric mucosa.3
CLDN18.2 is expressed in at least 60% of gastric cancers, as well as other cancers of the gastrointestinal tract, which makes it a compelling protein for targeted therapy.1,4,5
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1. Sahin U, Koslowski M, Dhaene K, et al. Clin Cancer Res. 2008;14(23):7624-7634. 2. Bailis JM, Lutterbuese P, Thomas O, et al. Presented at: AACR Virtual Annual Meeting II; June 22-24, 2020. Poster 3364. 3. Zhu G, Foletti D, Liu X, et al. Sci Rep. 2019;9(1):8420. 4. Jiang H, Shi Z, Wang P, et al. J Natl Cancer Inst. 2019;111(4):409-418. 5. Rohde C, Yamaguchi R, Mukhina S, Sahin U, Itoh K, Türeci Ö. Jpn J Clin Oncol. 2019;49(9):870-876.