Interleukin-21 receptor (IL-21R) is a type I cytokine receptor that is broadly expressed by hematopoietic cells, including T and B lymphocytes, natural killer cells, and myeloid cells. The IL-21R ligand, IL-21, is produced by activated CD4+ T cells and natural killer cells.1-3

IL-21, a potent mitogen and survival factor for activated T cells and natural killer cells, has emerged as a potential immunomodulator that acts on tumor-infiltrating lymphocytes to enhance the antitumor immune response.1,3

Learn more about modalities targeting IL-21R:
bifunctional fusion proteins.

Search our clinical trials.

Visit our resources section for additional information on potential oncogenic targets.

CD, cluster of differentiation.


1. Gattinoni L, Klebanoff CA, Restifo NP. Nat Rev Cancer. 2012;12(10):671-684. 2. Leonard WJ, Wan C-K. F1000Res. 2016;5:F1000. doi:10.12688/f1000research.7634.1. 3. Shen S, Sckisel G, Sahoo A, et al. Front Immunol. 2020;11:832. doi:10.3389/fimmu.2020.00832.