Interleukin-21 receptor (IL-21R) is a type I cytokine receptor that is broadly expressed by hematopoietic cells, including T and B lymphocytes, natural killer cells, and myeloid cells. The IL-21R ligand, IL-21, is produced by activated CD4+ T cells and natural killer cells.1-3
IL-21, a potent mitogen and survival factor for activated T cells and natural killer cells, has emerged as a potential immunomodulator that acts on tumor-infiltrating lymphocytes to enhance the antitumor immune response.1,3
Learn more about modalities targeting IL-21R:
bifunctional fusion proteins.
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Visit our resources section for additional information on potential oncogenic targets.
CD, cluster of differentiation.
1. Gattinoni L, Klebanoff CA, Restifo NP. Nat Rev Cancer. 2012;12(10):671-684. 2. Leonard WJ, Wan C-K. F1000Res. 2016;5:F1000. doi:10.12688/f1000research.7634.1. 3. Shen S, Sckisel G, Sahoo A, et al. Front Immunol. 2020;11:832. doi:10.3389/fimmu.2020.00832.