FMS-like tyrosine kinase 3 (FLT3) is a tyrosine kinase that is expressed by early hematopoietic progenitor cells, including some CD34+ cells.1,2 Binding to FLT3 ligand activates multiple cell signaling pathways, including proliferation and survival.2
FLT3 is highly expressed in leukemic blast cells in >70% of patients with acute myeloid leukemia (AML), which suggests that FLT3 plays a role in the survival and proliferation of leukemic blast cells.1,3
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CD: cluster of differentiation.
1. Gilliland DG, Griffin JD. Blood. 2002;100(5):1532-1542. 2. National Institutes of Health. https://ghr.nlm.nih.gov/gene/FLT3. Accessed 2/24/2021. 3. Carow CE, Levenstein M, Kaufmann SH, et al. Blood. 1996;87(3):1089-1096.