STEAP1

Six-transmembrane epithelial antigen of prostate 1 (STEAP1) is a membrane protein primarily expressed in the prostate tissue, where it is localized in the plasma membrane of epithelial cells located at cell-to-cell junctions.1 STEAP1 expression is low or absent in normal tissues, and its expression is increased in several types of human cancers.1,2

STEAP1 is overexpressed in > 80% of prostate cancers, including bone and lymph node metastases, representing an attractive target for treating metastatic castration-resistant prostate cancer (mCRPC).1-3

 

Download an educational resource for additional information on STEAP1, a therapeutic target in mCRPC.

 

Search our clinical trials.

Visit our resources section for additional information on potential oncogenic targets.

References

1. Gomes IM, Maia CJ, Santos CR. Mol Cancer Res. 2012;10(5):573-587. 2. Barroca-Ferreira J, Pais JP, Santos MM, et al. Curr Cancer Drug Targets. 2018;18(3):222-230. 3. Ihlaseh-Catalano SM, Drigo SA, de Jesus CM, et al. Histopathology. 2013;63(5):678-685.