Six-transmembrane epithelial antigen of prostate 1 (STEAP1) is a membrane protein primarily expressed in the prostate tissue, where it is localized in the plasma membrane of epithelial cells located at cell-to-cell junctions.1 STEAP1 expression is low or absent in normal tissues, and its expression is increased in several types of human cancers.1,2
STEAP1 is overexpressed in > 80% of prostate cancers, including bone and lymph node metastases, representing an attractive target for treating metastatic castration-resistant prostate cancer (mCRPC).1-3
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1. Gomes IM, Maia CJ, Santos CR. Mol Cancer Res. 2012;10(5):573-587. 2. Barroca-Ferreira J, Pais JP, Santos MM, et al. Curr Cancer Drug Targets. 2018;18(3):222-230. 3. Ihlaseh-Catalano SM, Drigo SA, de Jesus CM, et al. Histopathology. 2013;63(5):678-685.