FAP x 4-1BB

4-1BB (also known as CD137) is an activation-induced costimulatory molecule and an important regulator of immune responses.1

Amgen is investigating a molecule that is designed to bind with high affinity to fibroblast activation protein (FAP), which is abundantly expressed by cancer-associated fibroblasts in the majority of solid tumors in humans. Simultaneous binding of FAP and 4-1BB may result in clustering and immune cell activation.2


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1. Vinay DS, Kwon BS. BMB Rep. 2014;47(3):122-129. 2. Link A, Hepp J, Reichen C, et al. Poster presented at: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. Abstract 3752.