FAP x 4-1BB

4-1BB (also known as CD137) is an activation-induced costimulatory molecule and an important regulator of immune responses.1

Amgen is investigating a molecule that is designed to bind with high affinity to fibroblast activation protein (FAP), which is abundantly expressed by cancer-associated fibroblasts in the majority of solid tumors in humans. Simultaneous binding of FAP and 4-1BB may result in clustering and immune cell activation.2

 

Search our clinical trials.

Visit our resources section for additional information on potential oncogenic targets.

References

1. Vinay DS, Kwon BS. BMB Rep. 2014;47(3):122-129. 2. Link A, Hepp J, Reichen C, et al. Poster presented at: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. Abstract 3752.