FAP x 4-1BB

4-1BB, also called cluster of differentiation 137 (CD137), is a tumor necrosis factor receptor superfamily (TNFRSF) protein that acts as a costimulatory receptor for T cells.1 Fibroblast activation protein (FAP) is a transmembrane glycoprotein that is expressed by tumor stromal cells.2 Simultaneous binding of 4-1BB and FAP may induce localized immune cell activation.3


Learn more about modalities targeting FAP x 4-1BB:
DARPin® technology.

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Visit our resources section for additional information on potential oncogenic targets.

CD: cluster of differentiation.


1. Vinay DS, Kwon BS. BMB Rep. 2014;47(3):122-129. 2. Liu R, Li H, Liu L, et al. Cancer Biol Ther. 2012;13(3):123-129. 3. Link A, Hepp J, Reichen C, et al. Poster presented at: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. Abstract 3752.