EGFR is a transmembrane protein that promotes cell proliferation when activated.1 Deletion of exons 2-7 in the extracellular domain of EGFR results in a mutant form of the receptor, EGFRvIII, that cannot bind its ligands but is constitutively active with continuous downstream signaling and impaired degradation.2
It is estimated that up to 60% of EGFR-amplified glioblastomas have the EGFRvIII mutation, which is associated with poor prognosis and shorter survival. EGFRvIII is exclusively expressed in tumor cells, making it an attractive therapeutic target.2
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EGFR: epidermal growth factor receptor.
1. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/gene/1956. Accessed 4/5/2019. 2. Keller S, Schmidt MHH. Int J Mol Sci. 2017;18(6):E1295.