CAR—chimeric antigen receptors—are genetically engineered protein constructs that can be incorporated into a patient’s own cytotoxic T cells to help them recognize and fight cancer cells.1,2 This technology creates a new T cell receptor that binds to antigens found on tumor cells and activates the T cell in response to that binding.1
CAR T cell therapy is provided by removing or harvesting T cells from a patient with cancer, transfecting the cells with CAR genes that are directed against the patient’s tumor type, expanding the modified T cell population, and reinfusing the cells back into the patient.1
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CAR T: chimeric antigen receptor T cell.
1. National Cancer Institute, Dictionary of cancer terms: CAR T-cell therapy. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/car-t-cell-therapy. Accessed 4/5/2019. 2. American Cancer Society, CAR T-cell therapies. https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/car-t-cell1.html. Accessed 4/5/2019.