Peptides are small proteins comprised of short chains of amino acids.1 While peptides have functions and attributes that give them significant therapeutic potential, they tend to be rapidly cleared from the body.2
By fusing a peptide to part or all of an antibody, a peptibody combines the biological activity of a peptide with the longer duration of activity of an antibody. The resulting peptibody is composed of a biologically active peptide and an Fc region, which may broaden its therapeutic utility.2
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Fc: fragment crystallizable.
1. National Cancer Institute, Dictionary of cancer terms: peptide. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/peptide. Accessed 4/5/2019. 2. Shimamoto G, Gegg C, Boone T, Quéva C. Peptibodies: a flexible alternative format to antibodies. MAbs. 2012;4(5):586-591.