Antibody Drug Conjugate

Using antibodies to deliver cytotoxic drugs to cancer cells

An antibody drug conjugate (ADC) contains a drug which is bound to an antibody via a linker. The antibody is designed so that it specifically binds to a tumor antigen. Once bound, it is internalized and the antibody is believed to be degraded, and the drug is released.

Ducry L, Stump B. Antibody drug conjugates: Linking cytotoxic payloads to monoclonal antibodies. Bioconjug Chem. 2010;21:5-13.