The process of new blood vessel formation

Angiogenesis, the process of new blood vessel formation, is required for tumor growth and metastatic spread.1,2 This process is a complex one, resulting from the input of multiple signaling pathways.1,3 One such pathway is the angiopoietin axis, which is a separate and distinct pathway from the vascular endothelial growth factor (VEGF) axis.3,4

  1. Hanahan D, et al. Cell. 2000;100:57-70.
  2. Augustin HG, et al. Nat Rev Mol Cell Biol. 2009;10:165-177.
  3. Folkman J. Nat Rev Drug Discov. 2007;6:273-286.
  4. Huang H, et al. Nat Rev Cancer. 2010;10:575-585.