DARPin® molecules are single-domain or multi-domain engineered ankyrin repeat proteins, with each domain being one-tenth the size of a full antibody and having a constant framework and a variable target binding surface. DARPin® molecules are derived from natural ankyrin repeat proteins, a class of proteins often found in multi-domain formats. DARPin® binding domains with high affinity and specificity to a given target can be selected from large libraries (containing around 1012 individual binding molecules).1
Multispecific DARPin® molecules may be designed with the aim of eliciting differentiated biological activity.1
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DARPin® is a registered trademark owned by Molecular Partners AG.
1. Data on file, Amgen; 2020.