DARPin® TECHNOLOGY

DARPin® molecules are single-domain or multi-domain engineered ankyrin repeat proteins, with each domain being one-tenth the size of a full antibody and having a constant framework and a variable target binding surface. DARPin® molecules are derived from natural ankyrin repeat proteins, a class of proteins often found in multi-domain formats. DARPin® binding domains with high affinity and specificity to a given target can be selected from large libraries (containing around 1012 individual binding molecules).1

Multispecific DARPin® molecules may be designed with the aim of eliciting differentiated biological activity.1

Search our clinical trials.

Visit our resources section for further information on modalities currently under investigation.

DARPin® is a registered trademark owned by Molecular Partners AG.

Reference

1. Data on file, Amgen; 2020.