Redirecting T Cells

Redirecting T Cells Toward Cancer With Investigational BiTE® Molecules

Jonathan Benjamin, MD, PhD
Clinical Research Medical Director

Tumor Cells Are Often Recognized and Eliminated Through T-Cell–Mediated Immunosurveillance

  • Elimination—Immune cells mount the initial antitumor response1,2
  • Equilibrium—Insufficient elimination enables developing tumor to acquire tumor evasive mechanisms2
  • Escape—Tumor cell evasion results in cancer progression2
  1. Ochsenbein AF. Cancer Gene Ther. 2002;9:1043-1055.
  2. Swann JB, et al. J Clin Invest. 2007;117:1137-1146. Image adapted from Dunn GP, et al. Immunity. 2004;21:137-148.
T-cell-mediated immunosurveillance

CD, cluster of differentiation; NK, natural killer cell.

TCR Recognizes Antigens Presented by MHC Class I or II Molecules

  • Peptide antigen presentation by MHC molecules is required for TCR recognition
  • MHC class I presents peptides from endogenously synthesized proteins
  • MHC class II presents peptides from exogenously derived proteins

Murphy K. Janeway’s Immunobiology. 2012.

TCR recognition

APC, antigen-presenting cell; CD, cluster of differentiation; MHC, major histocompatibility complex; TCR, T-cell receptor.

Establishment of Immunological Synapse Facilitates Effector Function of Cytotoxic T Cells

  • T cell forms an immunological synapse with the target cell1
  • Lytic protein release by T cells induces target cell death2
  1. Rossy J, et al. Front Immunol. 2012;3:352.
  2. Chávez-Galán L, et al. Cell Mol Immunol. 2009;6:15-25.

Immunological Synapse

CD, cluster of differentiation; MHC, major histocompatibility complex; TCR, T-cell receptor.